热带病与寄生虫学

热带病与寄生虫学 ›› 2021, Vol. 19 ›› Issue (6): 319-321.

• 调查研究 • 上一篇    下一篇

阜阳市 HIV / AIDS 患者弓形虫感染情况调查

张远1,2,3,杜文燕1,吴建军4,蔡亦红1,2,3   

  1. 1. 安徽医科大学公共卫生学院卫生检验与检疫学系,安徽 合肥 230032;2. 安徽医科大学病原生物学安徽省重点实验室; 3. 安徽医科大学人畜共患病安徽高校省级重点实验室;4. 安徽省疾病预防控制中心
  • 出版日期:2021-12-20 发布日期:2021-12-31
  • 通信作者: 蔡亦红,E-mail:yihongcai@ yahoo. com
  • 作者简介:张远,男,硕士在读,研究方向:寄生虫感染与免疫。 E-mail:1078316270@ qq. com
  • 基金资助:
    国家自然科学基金项目(81572801)

Survey on Toxoplasma gondii prevalence in HIV / AIDS infected patients in Fuyang City

ZHANG Yuan1,2,3,DU Wen-yan1,2,3,WU Jian-jun4,CAI Yi-hong1,2,3   

  1. 1. Department of Health Inspection and Quarantine,School of Public Health,Anhui Medical University,Hefei 230032,Anhui Province,China;2. Anhui Provincial Laboratory of Microbiology and Parasitology,Anhui Medical University;3. Anhui Provincial Laboratory of Zoonoses of High Institutions,Anhui Medical University;4. Anhui Provincial Center for Disease Control and Prevention
  • Online:2021-12-20 Published:2021-12-31

PDF (PC)

602

摘要： 目的 了解安徽省阜阳市 HIV / AIDS 患者弓形虫的感染情况,以及弓形虫合并感染对患者 CD4+ T 淋巴细胞计数的影响,为 HIV / AIDS 患者弓形虫病防控提供参考依据。 方法 以安徽省阜阳市 2020 年 1 月至 2021 年 3 月未经治疗新报告的 HIV / AIDS 患者为调查对象,用酶联免疫吸附试验(ELISA)检测其血清弓形虫 IgG 抗体,同时检测 CD4+T 淋巴细胞水平。 结果 共调查 HIV / AIDS 患者 449 例,其中,男性 348 例,女性 75 例,36 例性别不详;年龄以 20~ 60 岁为主。 检测出弓形虫 IgG 抗体阳性 5 例,阳性率为 1. 11%。 弓形虫 IgG 抗体阴性的 HIV / AIDS 患者CD4+T 淋巴细胞计数最低为 1 个 / μL,最高为 1 616 个 / μL,中位数(四分位间距)为 287(170,439)个 / μL;弓形虫IgG 抗体阳性的 HIV / AIDS 患者 CD4+T 淋巴细胞计数最低为 43 个 / μL,最高为 325 个 / μL,中位数(四分位间距)为
139(86,237)个 / μL,两者间差异无统计学意义(Z = -1. 749,P>0. 05 )。 结论 安徽省阜阳市 HIV / AIDS 患者弓形虫感染率较低,CD4+T 淋巴细胞水平与弓形虫感染之间的关系有待进一步研究。

关键词: HIV / AIDS, 弓形虫, 阜阳市

Abstract: Objective To understand the status of Toxoplasma gondii(T. gondii) infection in patients infected with HIV /AIDS in Fuyang city of Anhui Province,and investigate the effect of co-infection on the count of CD4+T lymphocytes for evidence in prevention and control of T. gondii  infection in patients infected with HIV / AIDS. Methods The newly reported patients infected with HIV / AIDS without medication were included from January 2020 to March 2021 in Fuyang city. Enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum IgG antibody against T. gondii ,and the levels of CD4+T lymphocytes in all subjects. Results Totally,449 HIV / AIDS infected patients(348 males,75 females) underwent the survey. Thirty-six patients were unknown genders,and the patients aged from 20 to 60 years old. IgG antibody positive for T. gondii  was detected in 5 patients(1. 11%). CD4+T lymphocyte count was from the lowest 1 cell / μL to up to 1 616 cells / μL in patients with negative IgG antibody against T. gondii. The median ( interquartile range) was 287(170, 439) cells / μL. CD4+T lymphocyte count ranged minimally from 43 cells / μL to maximally 325 cells / μL in HIV / AIDS infected patients with IgG antibody positive for T. gondii ,with median ( interquartile range) of 139(86,237) cells / μL. The difference was insignificant in patients with negative or positive IgG T. gondii  antibody ( Z= -1. 749,P>0. 05). Conclusion T. gondii prevalence seems lower in HIV / AIDS infected patients in Fuyang city,and the relationship between CD4+T lymphocyte count and T. gondii  infection needs further investigating in such victims.

Key words: HIV / AIDS, Toxoplasma gondii, Fuyang City

中图分类号: