热带病与寄生虫学 ›› 2024, Vol. 22 ›› Issue (1): 1-6.doi: 10.3969/j.issn.1672-2302.2024.01.001

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猴痘病毒B.1谱系遗传分支、毒力基因及蛋白功能

林思宇1(), 陈芳1, 罗语思2,3(), 张科1()   

  1. 1.贵州医科大学基础医学院,贵州省微生物组与传染性疾病防控重点实验室,贵州 贵阳 561113
    2.贵州医科大学附属医院
    3.贵州医科大学附属医院六盘水医院
  • 收稿日期:2023-09-20 出版日期:2024-02-20 发布日期:2024-03-15
  • 通信作者: 罗语思,E-mail: 2608777366@qq.com;张科, E-mail: kezhang@gmc.edu.cn
  • 作者简介:林思宇,女,硕士在读,研究方向:病毒免疫学。E-mail: 1052479530@qq.com
  • 基金资助:
    贵州省卫生健康委科学技术基金项目(gzwkj2022-230)

Genetic branches, virulence genes, and protein functions of the mpox virus lineage B.1

LIN Siyu1(), CHEN Fang1, LUO Yusi2,3(), ZHANG Ke1()   

  1. 1. School of Basic Medicine, Guizhou Medical University; Key Laboratory of Microbio and Infectious Disease Prevention & Control in Guizhou Province, Guiyang 561113, Guizhou Province, China
    2. The Affiliated Hospital of Guizhou Medical University
    3. Liupanshui Hospital of the Affiliated Hospital of Guizhou Medical University
  • Received:2023-09-20 Online:2024-02-20 Published:2024-03-15
  • Contact: LUO Yusi,E-mail: 2608777366@qq.com;ZHANG Ke, E-mail: kezhang@gmc.edu.cn

摘要:

2022年以来,猴痘疫情在全球暴发和流行。相较以往的猴痘病毒,2022年流行的猴痘毒株传播能力和宿主适应性等明显增强,猴痘B.1谱系毒株已成为全球猴痘疫情流行的主要毒株。为此,本文对猴痘病毒B.1谱系遗传分支、毒力基因及蛋白功能进行综述,并就部分基因产物的蛋白功能进行了注释,以期为猴痘疫情的科学防控提供参考。

关键词: 猴痘病毒, B.1谱系毒株, 遗传分支, 毒力基因, 蛋白功能

Abstract:

Mpox virus has been outbreak and prevalent in many countries worldwide since 2022. Compared with the previous mpox virus strains, the 2022 epidemic mpox strains had gained significantly enhanced transmission ability and host adaptability, and the mpox lineage B.1 strains had become the dominant strains in the global epidemic of mpox. In this paper, we reviewed the genetic branches, virulence genes and protein functions of the mpox B.1 strains, and annotated the protein functions of some of the gene products, with an attempt to provide reference for the scientific prevention and control of mpox epidemics.

Key words: Mpox virus, Lineage B.1 strain, Genetic branches, Virulence gene, Protein function

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