Abstract: Objective To evaluate the outcomes of comprehensive prevention and control of schistosomiasis implemented in Hubei Province for a scientific basis to formulate following prevention and control plan for schistosomiasis infections. Methods The data on schistosomiasis prevention and control were initially obtained from the health, water conservancy, agriculture, forestry and other departments in 63 schistosomiasis-endemic counties (cities, districts) in Hubei Province from 2015 to 2024. Then a database was established to analyze the status of prevention and control measures implemented, the achievement of major work indicators, and the effectiveness of schistosomiasis comprehensively prevention and control was evaluated. Results From 2015 to 2024, a total of 12.018 2 million person-times in Hubei Province underwent inquiry examination for schistosomiasis, and 2.052 million person-times of them with positive results. A total of 10.744 8 million person-times of population were subjected to serology tests for the disease screening, and 213 400 person-times with positive findings received further confirmation. Fecal examination were completed for 406 500 person-times, and no positive fecal test results were found since 2016. A total of 1.501 8 million head-times of livestock underwent screening for schistosomiasis, yet no positive cases in farm cattle had been detected since 2015. Snail surveys were conducted in an area of 1.506 6 million hm2, where Oncomelania hupensis was newly discovered in an area of 133.34 hm², and snail resurgence was identified in an area of 1 066.32 hm². No infectious Oncomelania hupensis had been detected since 2015, and the area with positive Oncomelania hupensis remained at 0. Among the 63 endemic counties (cities and districts) in the province, 43 have met the elimination criteria and 20 have met the transmission blocking criteria. Conclusion From 2015 to 2024, the comprehensive prevention and control of schistosomiasis in Hubei Province, mainly focusing on the control of infection sources, achieved relatively remarkable results. In the next stage, it is necessary to strengthen risk monitoring, enhance inter-departmental collaboration, optimize team building, and ensure the achievement of the goal of eliminating schistosomiasis.

Key words: Schistosomiasis, Comprehensive control, Effect evaluation, Oncomelania hupensis, Hubei Province